Endocrine Abstracts

We audited 46 pituitary MRI scans for patients with hypogonadotropic hypogonadism. We were particularly interested to see if adopting The Endocrine Society’s (TES) 2010 guidelines for Testosterone Therapy in Men with Androgen Deficiency Syndromes (pituitary MRIs only for those with testosterone level below 5.3 mmol/l, panhypopituitarism, persistent hyperprolactinaemia or if the patient has symptoms consistent with a mass effect such as headaches, a visual field defect or ...

Patients with Familial Hypercholesterolaemia (FH) have premature Cardiovascular disease and have a standardised mortality ratio nine times greater than normal. FH must therefore be correctly diagnosed and treated aggressively. Referral for FH is based on fulfilling the Simon Broome’s (SB) Criteria. We aimed to evaluate practice at Queen Alexandra Hospital with regards to referral for FH genetic mutation. We set out to see whether SB’s criteria were being fulfilled wh...

We present a 65-year-old lady initially diagnosed and treated for epilepsy who was subsequently referred 10 years later for the investigation of underlying spontaneous hypoglycaemia. Laboratory plasma glucose concentrations of 2.0 and 1.7 mmol/l were recorded prior to referral and subsequently a fasting challenge provoked hypoglycaemia associated with a plasma glucose of 0.8 mmol/l, C-peptide 371 pmol/l (NR 120–600) and insulin 7.4 mU/l (NR 0–10). CT and MRI imaging ...

A 30 year old woman presented at 15 weeks gestation with resistant hypertension (that had been diagnosed prior to pregnancy) and hypokalaemia (2.8 mmol/l). Subsequent tests, whilst on Nifedipine, showed a markedly raised aldosterone/renin ratio of 267 (n<25) [Aldosterone 720 ng/L;Renin 3 mu/L] (Aldosterone reference range: Supine:20–190 ng/L, Ambulant 30–340 ng/L; Renin reference range: Supine 2–30 mu/L, Ambulant 3–40 mu/L).<p class="a...

Background: We previously published data for short-term outcomes in patients with SIADH-related hyponatraemia unresponsive to fluid restriction and treated with tolvaptan. In light of concerns over longer-term side-effects we have revisited the topic and extended both group size and follow-up period to determine longer-term safety and treatment implications.Aims/methods: We report ongoing treatment outcomes (case-note review) for 25 patients (age 71&#177...

Prior to May 2011, we ran four separate consultant-led endocrine services with six-eight new patient referrals identifiable per week with hyperthyroidism. These were seen ‘ad hoc’ in general endocrine clinics, where their needs were not prioritised compared to other endocrine referrals, resulting in concern around the timeliness of their care.We identified 203 patients under active follow-up (FU) (active=on anti-thyroid medications or within 6 ...